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STEROID 11-BETA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 11-beta-Hydroxylase
Descriptor
Spanish
:
Esteroide 11-beta-Hidroxilasa
Descriptor
Portuguese
:
Esteroide 11-beta-Hidroxilase
Synonyms
English
:
CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Steroid 11-beta-Monooxygenase
Tree Number:
D08.244.453.915.750
D08.811.682.690.708.170.915.750
D08.811.682.690.708.783.750
D12.776.422.220.453.915.750
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of
CORTICOSTERONE
and
HYDROCORTISONE
. Defects in CYP11B1 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 11-beta-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
See Related
English
:
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23463
Unique Identifier:
D013252
Occurrence in VHL
:
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